Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 2/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KLK7 | P49862 | 3/20 | 0.41 |
| ▸ | KLK14 | Q9P0G3 | 3/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27248843 | 0.90 | ENPP1 (0.47) | ENPP1TNFALDH1A1KLK7KLK14 | |
| SCHEMBL27248716 | 0.89 | ENPP1 (0.46) | ENPP1TNFALDH1A1KLK7KLK14 | |
| SCHEMBL7164349 | 0.87 | ENPP1 (0.58) | ENPP1TNFALDH1A1HTTEGFR | |
| SCHEMBL27882455 | 0.85 | ENPP1 (0.55) | ENPP1TNFALDH1A1KLK7KLK14 | |
| SCHEMBL11490691 | 0.83 | DHFR (0.48) | ENPP1TNFKLK7KLK14KLK5 | |
| SCHEMBL7089286 | 0.82 | ENPP1 (0.52) | ENPP1ALDH1A1KLK7KLK14KLK5 | |
| SCHEMBL27882447 | 0.82 | ENPP1 (0.46) | ENPP1TNFALDH1A1KLK7KLK14 | |
| SCHEMBL11556425 | 0.82 | ENPP1 (0.68) | ENPP1TNFALDH1A1HTTEGFR | |
| SCHEMBL23260607 | 0.81 | ENPP1 (0.59) | ENPP1TNFALDH1A1HTTEGFR | |
| SCHEMBL14952547 | 0.81 | ENPP1 (0.59) | ENPP1TNFALDH1A1HTTEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0919233-B1 | THERAPEUTIC AGENT FOR KIDNEY DISEASES | KYOWA HAKKO KOGYO KK (JP) | 2003-06-04 | — | — | EP | disclosed |
| EP-0726267-B1 | QUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2000-11-22 | — | — | EP | disclosed |
| US-5948784-A | NEPHRITIS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0919233-A1 | THERAPEUTIC AGENT FOR KIDNEY DISEASES | KYOWA HAKKO KOGYO KABUSHIKI KAISHA (JP) | 1999-06-02 | — | — | EP | disclosed |
| EP-0726267-A1 | QUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-08-14 | — | — | EP | disclosed |