Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 5/20 | 0.56 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.56 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943695 | 1.00 | OXTR (0.56) | OXTRAVPR1ASPRROCK2ROCK1 | |
| SCHEMBL4949347 | 0.92 | OXTR (0.58) | OXTRAVPR1AMEN1KMT2AATM | |
| SCHEMBL4942161 | 0.87 | OXTR (0.54) | OXTRAVPR1ASPRROCK2ROCK1 | |
| SCHEMBL4943223 | 0.86 | OXTR (0.59) | OXTRAVPR1AOPRM1 | |
| SCHEMBL7162141 | 0.86 | OXTR (0.73) | OXTRAVPR1AMEN1KMT2ATSHR | |
| SCHEMBL5759282 | 0.85 | OXTR (0.73) | OXTRAVPR1AMEN1KMT2AATM | |
| SCHEMBL4942676 | 0.85 | OXTR (0.73) | OXTRAVPR1AMEN1KMT2AATM | |
| SCHEMBL4945500 | 0.84 | OXTR (0.61) | OXTRAVPR1ASMN1; SMN2KMT2A | |
| SCHEMBL5133132 | 0.81 | AVPR1A (0.63) | OXTRAVPR1A | |
| SCHEMBL5743871 | 0.81 | OXTR (0.84) | OXTRAVPR1AROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | claimed |
| EP-1268418-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | Applied Research Systems ARS Holding N.V. (AN) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001074769-A1 | PHARMACEUTICALLY ACTIVE PYRROLIDINE DERIVATIVES AS BAX INHIBITORS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-10-11 | — | — | WO | disclosed |