SCHEMBL7165474

SCHEMBL7165474

Cc1cc(NC(=O)C(=O)O)cc(C)c1Oc1ccc(O)c(NC(=O)NC(C)c2ccccc2I)c1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
THRA P10827 4/20 0.59
THRB P10828 4/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7032801 0.88 THRA (0.61) THRATHRB
SCHEMBL7027393 0.77 THRA (0.57) THRATHRB
SCHEMBL7031277 0.76 THRA (0.58) THRATHRB
SCHEMBL7023286 0.76 THRA (0.58) THRATHRB
SCHEMBL7060025 0.76 THRB (0.55) THRATHRB
SCHEMBL281877 0.75 THRA (1.00) THRATHRB
SCHEMBL29373673 0.75 THRA (1.00) THRATHRB
SCHEMBL7032024 0.74 THRA (0.61) THRATHRB
SCHEMBL6663090 0.74 THRA (0.58) THRATHRB
SCHEMBL7024880 0.74 THRB (0.57) THRATHRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6555580-B2 Treating arteriosclerosis and hypercholesterolaemia BAYER AKTIENGESELLSCHAFT (DE) 2003-04-29 US disclosed