Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 15/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790607 | 0.98 | FDPS (0.96) | FDPSNPC1RAB9ALMNAMETAP2 | |
| SCHEMBL9790621 | 0.89 | FDPS (0.79) | FDPSNPC1RAB9ALMNAMETAP2 | |
| Silver SCHEMBL9790847 | 0.89 | FDPS (0.79) | FDPSNPC1RAB9ALMNAMETAP2 | |
| SCHEMBL9790837 | 0.80 | FDPS (0.67) | FDPSNPC1RAB9ALMNAMETAP2 | |
| SCHEMBL19468539 | 0.74 | FDPS (0.58) | FDPSNPC1RAB9ALMNAMETAP2 | |
| SCHEMBL9790861 | 0.74 | FDPS (0.58) | FDPSNPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL28772849 | 0.71 | — | — | |
| SCHEMBL9790758 | 0.70 | FDPS (0.54) | FDPS | |
| SCHEMBL9790600 | 0.70 | FDPS (0.54) | FDPS | |
| SCHEMBL4129461 | 0.70 | ACP1 (0.58) | FDPSNPC1RAB9ALMNAMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255288-B1 | THERAPY FOR BONE DISORDERS | NOVARTIS CORPORATION | 2001-07-03 | — | — | US | claimed |
| EP-0998934-A1 | REMEDIES FOR INTRAMEDULLARY DISEASES | TORAY INDUSTRIES, INC. (JP) | 2000-05-10 | — | — | EP | claimed |
| EP-0550385-A1 | Oral pharmaceutical compositions containing derivatives of methane-diphosphonic acid and 18-crown-6 ethers | CIBA-GEIGY AG (CH) | 1993-07-07 | — | — | EP | claimed |
| US-5133972-A | TOPICALLY ADMINISTRABLE PHARMACEUTICAL PREPARATIONS | CIBA-GEIGY CORPORATION (US) | 1992-07-28 | — | — | US | claimed |
| US-5057505-A | Treatment of illnesses attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | claimed |
| EP-0274346-B1 | SUBSTITUTED AMINOMETHANE-DIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | claimed |
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | claimed |
| US-6555529-B1 | Administering (4-methylthiophenylthio)methane-1,1-bisphosphonic acid for treatment of bone marrow disorders such as inflammatory disease, myeloma, anemia, and leukemia | TORAY INDUSTRIES, INC. (JP) | 2003-04-29 | — | — | US | disclosed |
| US-6255288-B1 | THERAPY FOR BONE DISORDERS | NOVARTIS CORPORATION | 2001-07-03 | — | — | US | disclosed |
| EP-0998934-A1 | REMEDIES FOR INTRAMEDULLARY DISEASES | TORAY INDUSTRIES, INC. (JP) | 2000-05-10 | — | — | EP | disclosed |
| EP-0600834-A1 | Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing | CIBA-GEIGY AG (CH) | 1994-06-08 | — | — | EP | disclosed |
| US-5296475-A | Methanediphosphonic acids and crown compounds for treatment of bone disorders or hypercalcemia | CIBA-GEIGY CORPORATION (US) | 1994-03-22 | — | — | US | disclosed |
| EP-0550385-A1 | Oral pharmaceutical compositions containing derivatives of methane-diphosphonic acid and 18-crown-6 ethers | CIBA-GEIGY AG (CH) | 1993-07-07 | — | — | EP | disclosed |
| US-5133972-A | TOPICALLY ADMINISTRABLE PHARMACEUTICAL PREPARATIONS | CIBA-GEIGY CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| US-5057505-A | Treatment of illnesses attributed to calcium metabolism disorders | CIBA-GEIGY CORPORATION (US) | 1991-10-15 | — | — | US | disclosed |
| EP-0274346-B1 | SUBSTITUTED AMINOMETHANE-DIPHOSPHONIC ACIDS | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |
| EP-0282309-A2 | Azole-aminomethylene bisphosphonic acid derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-09-14 | — | — | EP | disclosed |
| EP-0274346-A1 | Substituted aminomethane-diphosphonic acids | CIBA-GEIGY AG (CH) | 1988-07-13 | — | — | EP | disclosed |