Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | GLA | P06280 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20780149 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL715791 | 0.87 | ALDH1A1 (0.57) | KDM4EALDH1A1GLAGAACYP2D6 | |
| SCHEMBL20767986 | 0.87 | KDM4E (0.56) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL716590 | 0.85 | ALDH1A1 (0.57) | KDM4EALDH1A1GLAGAACYP2D6 | |
| SCHEMBL726886 | 0.84 | ALDH1A1 (0.56) | KDM4EALDH1A1GLAGAACYP2D6 | |
| SCHEMBL4211454 | 0.83 | ALDH1A1 (0.60) | KDM4EALDH1A1GLAGAACYP2D6 | |
| SCHEMBL15654259 | 0.80 | CYP2D6 (0.46) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL18135307 | 0.80 | CA12 (0.54) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL532709 | 0.79 | KDM4E (0.48) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL4206426 | 0.78 | MAOA (0.64) | CYP2D6CYP2C19CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790536-B2 | Methods for assaying alpha-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2015-12-10 | — | — | US | disclosed |
| US-9012663-B2 | Methods for assaying α-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2015-04-21 | — | — | US | disclosed |
| EP-2191006-B1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIV WASHINGTON (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20120052519-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2012-03-01 | — | — | US | disclosed |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120052519-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885HPGD 1422/4885 |
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885HPGD 1422/4885 |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885HPGD 1422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.