Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170402 | 0.85 | HPGD (0.51) | HPGDALDH1A1MAPK1LMNAMAPT | |
| SCHEMBL10666776 | 0.79 | HDAC1 (0.56) | HPGDALDH1A1HTR1AHDAC1HDAC7 | |
| SCHEMBL10667117 | 0.79 | HDAC1 (0.56) | HPGDALDH1A1HTR1AHDAC1HDAC7 | |
| SCHEMBL6510657 | 0.77 | HDAC1 (0.58) | HPGDALDH1A1MAPTDRD3HDAC1 | |
| SCHEMBL6966437 | 0.77 | HDAC1 (0.58) | HPGDALDH1A1MAPTDRD3HDAC1 | |
| SCHEMBL21316650 | 0.76 | HDAC1 (0.56) | HPGDALDH1A1HTR1AHDAC1HDAC7 | |
| SCHEMBL11686163 | 0.76 | HDAC1 (0.59) | HPGDALDH1A1MAPTDRD3HDAC1 | |
| SCHEMBL5094698 | 0.75 | HDAC1 (0.62) | ALDH1A1MAPTHTR1ADRD3HDAC1 | |
| SCHEMBL7274059 | 0.75 | HDAC1 (0.55) | HPGDALDH1A1HDAC1HDAC7TDP1 | |
| SCHEMBL7021054 | 0.74 | HDAC1 (0.58) | HPGDALDH1A1MAPTHDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027056-B1 | ALPHA-KETOAMIDE MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2009-02-25 | — | — | EP | disclosed |
| CN-1166403-C | Multicatalytic protease inhibitors | — | 2004-09-15 | — | — | CN | disclosed |
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5990083-A | Multicatalytic protease inhibitors | CEPHALON, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5830870-A | PREVENT LOSS OF MUSCLE MASS | CEPHALON, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| CN-1164192-A | Inhibitors of heterogeneously catalyzed proteases | CEPHALON INC (US) | 1997-11-05 | — | — | CN | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5614649-A | TREATMENT OF MUSCULAR DISORDERS, SUBSTITUTED GUANIDINES | CEPHALON, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5550262-A | TREATMENT OF MUSCLES WASTING DISEASES | CEPHALON, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |