Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166061 | 0.85 | HPGD (0.58) | HPGDALDH1A1MAPK1TDP1L3MBTL1 | |
| SCHEMBL7167353 | 0.81 | CYP3A4 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19HDAC1 | |
| SCHEMBL8967773 | 0.81 | CYP3A4 (0.48) | ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7172023 | 0.79 | CYP3A4 (0.46) | ALDH1A1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7167070 | 0.77 | CYP3A4 (0.46) | ALDH1A1MAPK1L3MBTL1LMNAMAPT | |
| SCHEMBL6578347 | 0.77 | TDP1 (0.51) | ALDH1A1MAPK1TDP1L3MBTL1LMNA | |
| SCHEMBL9327800 | 0.75 | TDP1 (0.48) | HPGDALDH1A1TDP1L3MBTL1LMNA | |
| SCHEMBL9327808 | 0.75 | TDP1 (0.48) | HPGDALDH1A1TDP1L3MBTL1LMNA | |
| SCHEMBL408911 | 0.75 | TDP1 (0.49) | HPGDALDH1A1MAPK1TDP1L3MBTL1 | |
| SCHEMBL7167403 | 0.74 | CYP3A4 (0.45) | L3MBTL1MAPTCYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5990083-A | Multicatalytic protease inhibitors | CEPHALON, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5830870-A | PREVENT LOSS OF MUSCLE MASS | CEPHALON, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5614649-A | TREATMENT OF MUSCULAR DISORDERS, SUBSTITUTED GUANIDINES | CEPHALON, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |