SCHEMBL7166259

SCHEMBL7166259

CCON=Cc1cc(N=C=O)c(Cl)cc1Cl

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
TRPA1 O75762 1/20 0.31
CYP3A4 P08684 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7931192 0.88
SCHEMBL7000738 0.84 TDP1 (0.35) MAPK1TDP1TRPA1CYP3A4
SCHEMBL7000734 0.84 TDP1 (0.35) MAPK1TDP1TRPA1CYP3A4
SCHEMBL7931311 0.82 MAPK1 (0.49) MAPK1TDP1TRPA1CYP3A4
SCHEMBL7162945 0.74 NPC1 (0.38) TDP1
SCHEMBL7893961 0.73 TDP1 (0.46) MAPK1TDP1TRPA1CYP3A4
SCHEMBL7001988 0.71 ALDH1A1 (0.33) TDP1CYP3A4
SCHEMBL7001983 0.71 ALDH1A1 (0.33) TDP1CYP3A4
SCHEMBL9835490 0.71 KDM4E (0.39) MAPK1TDP1TRPA1CYP3A4
SCHEMBL1493025 0.70 TDP1 (0.52) MAPK1TDP1TRPA1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0879239-B1 SUBSTITUTED AROMATIC PHOSPHONIC ACID DERIVATIVES BASF AG (DE) 2003-04-23 EP disclosed
EP-0879239-A1 SUBSTITUTED AROMATIC PHOSPHONIC ACID DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 1998-11-25 EP disclosed
WO-1997030060-A1 SUBSTITUTED AROMATIC PHOSPHONIC ACID DERIVATIVES BASF AKTIENGESELLSCHAFT (DE) 1997-08-21 WO disclosed