Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 4/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD5 | P21918 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2963311 | 0.88 | KCNH2 (0.47) | DRD2DRD3HTR2ADRD4CACNA1F | |
| SCHEMBL6997428 | 0.86 | DRD2 (0.41) | DRD2DRD3HTR2ADRD4CACNA1F | |
| SCHEMBL5965538 | 0.81 | DRD3 (0.40) | DRD2DRD3HTR2ADRD4CACNA1F | |
| SCHEMBL2961534 | 0.75 | KCNH2 (0.52) | DRD2HTR2AHTR2CCCR3KCNH2 | |
| SCHEMBL3130292 | 0.74 | KCNH2 (0.55) | DRD2DRD3HTR2ADRD4HTR1A | |
| SCHEMBL7248526 | 0.72 | NSD2 (0.40) | DRD2DRD3HTR2ADRD4CACNA1F | |
| SCHEMBL3124734 | 0.71 | KCNH2 (0.57) | DRD2DRD3KCNH2THRBPRKAA2 | |
| SCHEMBL3129028 | 0.71 | KCNH2 (0.57) | DRD2DRD3KCNH2THRBPRKAA2 | |
| SCHEMBL2966844 | 0.71 | KCNH2 (0.41) | DRD2DRD3HRH2HTR7HRH1 | |
| SCHEMBL7166109 | 0.71 | HRH3 (0.44) | HRH2HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559143-B1 | Class III electrophysiological activity, drugs which prolong the trans-membrane action potential duration and refractoriness, without affecting cardiac conduction | ASTRAZENECA AB (SE) | 2003-05-06 | — | — | US | claimed |