Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167160 | 1.00 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL27286692 | 1.00 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL9782310 | 0.89 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL9782307 | 0.89 | ALDH1A1 (0.52) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL9782445 | 0.89 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL9782435 | 0.89 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL31389132 | 0.85 | L3MBTL1 (0.61) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7954572 | 0.84 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7775216 | 0.84 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7954574 | 0.84 | ALDH1A1 (0.55) | L3MBTL1ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6559149-B1 | Lesser side effects without compromise in their efficacy | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-05-06 | — | — | US | disclosed |
| EP-0632038-B1 | METHOTREXATE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2001-08-22 | — | — | EP | disclosed |
| CN-1039907-C | Methotrexate derivative | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1998-09-23 | — | — | CN | disclosed |
| EP-0632038-A1 | METHOTREXATE DERIVATIVE | Chugai Seiyaku Kabushiki Kaisha (JP) | 1995-01-04 | — | — | EP | disclosed |
| CN-1077956-A | METHOTREXATE DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 1993-11-03 | — | — | CN | disclosed |
| US-5019577-A | Novel compounds and use | BURROUGHS WELCOME CO. (US) | 1991-05-28 | — | — | US | disclosed |