Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804101 | 0.85 | TGFBR1 (0.44) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL27586600 | 0.81 | JAK2 (0.42) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL23150464 | 0.79 | JAK3 (0.59) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL23150425 | 0.76 | JAK2 (0.49) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL16278661 | 0.76 | RET (0.41) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL16278662 | 0.76 | RET (0.41) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL7138358 | 0.76 | ABL1 (0.52) | EGFRLCKFYNSRCKDR | |
| SCHEMBL23150533 | 0.75 | JAK2 (0.54) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL17267635 | 0.74 | DYRK3 (0.47) | JAK2JAK3EGFRDYRK3CDK1 | |
| SCHEMBL5802174 | 0.74 | JAK2 (0.67) | JAK2JAK3EGFRDYRK3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1520298-A | Pyrazolopyrimidines as therapeutic agents | �����ʩ���عɷݹ�˾ | 2004-08-11 | — | — | CN | disclosed |
| US-6660744-B1 | Kinase inhibitors | ABBOTT GMBH & CO. KG (DE) | 2003-12-09 | — | — | US | disclosed |
| CN-1390219-A | Pyrazolopyrimidines as therapeutic agents | ABBOTT AG (DE) | 2003-01-08 | — | — | CN | disclosed |