Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8967773 | 0.88 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP2C19ALDH1A1DPP4 | |
| SCHEMBL7172023 | 0.85 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL7167070 | 0.83 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL7167403 | 0.81 | CYP3A4 (0.45) | CYP3A4CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL7170402 | 0.81 | HPGD (0.51) | CYP3A4CYP2C9CYP2C19ALDH1A1HDAC1 | |
| SCHEMBL28688698 | 0.80 | CYP3A4 (0.56) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL7412438 | 0.79 | CYP3A4 (0.54) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL7409492 | 0.79 | CYP3A4 (0.54) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL7169912 | 0.78 | CYP3A4 (0.40) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 | |
| SCHEMBL12606879 | 0.78 | CYP3A4 (0.53) | CYP3A4CYP2C9CYP2C19ALDH1A1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5990083-A | Multicatalytic protease inhibitors | CEPHALON, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5830870-A | PREVENT LOSS OF MUSCLE MASS | CEPHALON, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| CN-1164192-A | Inhibitors of heterogeneously catalyzed proteases | CEPHALON INC (US) | 1997-11-05 | — | — | CN | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5614649-A | TREATMENT OF MUSCULAR DISORDERS, SUBSTITUTED GUANIDINES | CEPHALON, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |