Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.39 |
| ▸ | KLK7 | P49862 | 2/20 | 0.39 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167070 | 0.88 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19MAPTKMT2A | |
| SCHEMBL7406434 | 0.84 | CYP3A4 (0.50) | CYP3A4CYP2C9CYP2C19CTSLKMT2A | |
| SCHEMBL7406437 | 0.84 | CYP3A4 (0.50) | CYP3A4CYP2C9CYP2C19CTSLKMT2A | |
| SCHEMBL8967773 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP2C19ITGB3ITGA2B | |
| SCHEMBL7167353 | 0.81 | CYP3A4 (0.48) | CYP3A4CYP2C9CYP2C19KMT2AMEN1 | |
| SCHEMBL28635941 | 0.80 | SYK (0.46) | MAPTKMT2AL3MBTL1MEN1SYK | |
| SCHEMBL3546854 | 0.79 | MAPT (0.45) | MAPTL3MBTL1SYK | |
| SCHEMBL3546849 | 0.79 | MAPT (0.45) | MAPTL3MBTL1SYK | |
| SCHEMBL7172023 | 0.79 | CYP3A4 (0.46) | CYP3A4CYP2C9CYP2C19CTSLKMT2A | |
| SCHEMBL14037218 | 0.78 | LTA4H (0.50) | MAPTL3MBTL1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789578-B1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0789578-A4 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON INC (US) | 2000-09-20 | — | — | EP | disclosed |
| US-5990083-A | Multicatalytic protease inhibitors | CEPHALON, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| US-5830870-A | PREVENT LOSS OF MUSCLE MASS | CEPHALON, INC. (US) | 1998-11-03 | — | — | US | disclosed |
| EP-0789578-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5614649-A | TREATMENT OF MUSCULAR DISORDERS, SUBSTITUTED GUANIDINES | CEPHALON, INC. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5550262-A | TREATMENT OF MUSCLES WASTING DISEASES | CEPHALON, INC. (US) | 1996-08-27 | — | — | US | disclosed |
| WO-1996014857-A1 | MULTICATALYTIC PROTEASE INHIBITORS | CEPHALON, INC. (US) | 1996-05-23 | — | — | WO | disclosed |