Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7168846 | 0.93 | HRH3 (0.47) | HRH3DRD3SIGMAR1BCHEMAOA | |
| SCHEMBL7163046 | 0.82 | DRD3 (0.52) | HRH3DRD3HRH4SLC6A2SLC6A4 | |
| SCHEMBL15664017 | 0.80 | HRH3 (0.62) | HRH3DRD3SIGMAR1MEN1KMT2A | |
| SCHEMBL7164657 | 0.78 | DRD3 (0.47) | HRH3DRD3SIGMAR1METKDM4E | |
| SCHEMBL10807692 | 0.76 | HRH3 (0.70) | HRH3DRD3SIGMAR1NPC1RAB9A | |
| SCHEMBL7139103 | 0.74 | HRH3 (0.46) | HRH3DRD3METKDM4EFGFR1 | |
| SCHEMBL4664117 | 0.74 | SRC (0.46) | HRH3DRD3ACHEMETSRC | |
| SCHEMBL7144131 | 0.72 | LTA4H (0.65) | HRH3DRD3 | |
| SCHEMBL7167588 | 0.71 | KMT2A (0.43) | HRH3ACHEKMT2AKDM4EHRH4 | |
| SCHEMBL28032867 | 0.71 | HRH3 (0.62) | HRH3DRD3SIGMAR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313726-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | AstraZeneca AB (SE) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002012226-A1 | QUINOLINE DERIVATIVES HAVING VEGF INHIBITING ACTIVITY | ASTRAZENECA AB (SE) | 2002-02-14 | — | — | WO | disclosed |