Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 3/20 | 0.57 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888965 | 0.90 | PIK3CA (0.62) | CCNE2CCNE1CDK2MAPTPIK3CA | |
| SCHEMBL2801822 | 0.87 | PIK3CA (0.66) | CCNE2CCNE1CDK2MAPTPIK3CA | |
| SCHEMBL14810937 | 0.85 | ALDH1A1 (0.78) | ALDH1A1MAPTGBA1KMT2ASMN1; SMN2 | |
| SCHEMBL28736417 | 0.84 | PIK3CA (0.57) | CCNE2CCNE1CDK2ALDH1A1MAPT | |
| SCHEMBL27221084 | 0.82 | CCNE2 (0.71) | CCNE2CCNE1CDK2ALDH1A1MAPT | |
| SCHEMBL163906 | 0.81 | PIK3CA (0.75) | CCNE2CCNE1CDK2MAPTPIK3CA | |
| SCHEMBL6335176 | 0.80 | CA1 (0.57) | ALDH1A1MAPTPIK3CASMN1; SMN2CYP1A2 | |
| SCHEMBL14810305 | 0.77 | MAPT (0.69) | ALDH1A1MAPTGBA1KMT2ASMN1; SMN2 | |
| SCHEMBL23431538 | 0.77 | MAPT (0.48) | CCNE2CCNE1CDK2ALDH1A1MAPT | |
| SCHEMBL10359051 | 0.77 | ALDH1A1 (0.89) | ALDH1A1MAPTGBA1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573377-B1 | Antitumor agent capable of showing its efficacy even against 5- FU drug resistant tumors | DAIICHI PHARMACEUTICALS CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| EP-1103551-A1 | PYRAZOLE DERIVATIVES AND SALTS THEREOF | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-05-30 | — | — | EP | disclosed |