Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5888965 | 0.97 | PIK3CA (0.62) | PIK3CAMAPTSMN1; SMN2CLK1CLK2 | |
| SCHEMBL28736417 | 0.91 | PIK3CA (0.57) | PIK3CAMAPTSMN1; SMN2CLK1CLK2 | |
| SCHEMBL163906 | 0.91 | PIK3CA (0.75) | PIK3CAMAPTSMN1; SMN2CLK1CLK2 | |
| SCHEMBL7168459 | 0.87 | CCNE2 (0.57) | PIK3CAMAPTSMN1; SMN2CLK1CLK2 | |
| SCHEMBL6335176 | 0.85 | CA1 (0.57) | PIK3CAMAPTSMN1; SMN2CA12CA1 | |
| SCHEMBL10055023 | 0.85 | CA9 (0.68) | PIK3CACA12CA1CA2CA9 | |
| SCHEMBL7169729 | 0.85 | MAPT (0.54) | PIK3CAMAPTSMN1; SMN2CLK1CLK2 | |
| SCHEMBL27284393 | 0.84 | CLK4 (0.56) | PIK3CASMN1; SMN2CLK1CLK2DYRK1A | |
| SCHEMBL23990593 | 0.83 | NPC1 (0.51) | PIK3CAMAPTCLK1CLK2DYRK1A | |
| SCHEMBL15619030 | 0.82 | CCNE2 (0.68) | PIK3CAMAPTCLK1CLK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108191774-B | Heterocyclic compound, preparation method and application thereof | 中国药科大学 | 2022-05-24 | — | — | CN | disclosed |
| WO-2020146779-A1 | mTORC1 INHIBITORS FOR ACTIVATING AUTOPHAGY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-07-16 | — | — | WO | disclosed |
| WO-2018175958-A1 | THIOREDOXIN MODULATORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-27 | — | — | WO | disclosed |
| US-20100239500-A1 | SUBSTITUTED TRIAZINE COMPOUNDS FOR NERVE REGENERATION | UNIVERSITY OF MIAMI | 2010-09-23 | — | — | US | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718655-B2 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2010-05-18 | — | — | US | disclosed |
| US-7115737-B2 | Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling | NEW YORK UNIVERSITY (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1441683-A4 | TRISUBSTITUTED TRIAZINE COMPOUNDS, AND METHODS FOR MAKING AN USING THE COMPOUNDS, WHICH HAVE ANTITUBULIN ACTIVITY | UNIV NEW YORK (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004099163-A1 | SOLID PHASE SYNTHESIS OF BIARYL TRIAZINE LIBRARY BY SUZUKI CROSS-COUPLING REACTION | NEW YORK UNIVERSITY (US) | 2004-11-18 | — | — | WO | disclosed |
| US-20040225125-A1 | Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling | NEW YORK UNIVERSITY (US) | 2004-11-11 | — | — | US | disclosed |
| EP-1441683-A2 | TRISUBSTITUTED TRIAZINE COMPOUNDS, AND METHODS FOR MAKING AN USING THE COMPOUNDS, WHICH HAVE ANTITUBULIN ACTIVITY | NEW YORK UNIVERSITY (US) | 2004-08-04 | — | — | EP | disclosed |
| US-20040122009-A1 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | NEW YORK UNIVERSITY (US) | 2004-06-24 | — | — | US | disclosed |
| US-6573377-B1 | Antitumor agent capable of showing its efficacy even against 5- FU drug resistant tumors | DAIICHI PHARMACEUTICALS CO., LTD. (JP) | 2003-06-03 | — | — | US | disclosed |
| WO-2003032903-A2 | TRISUBSTITUTED TRIAZINES COMPOUNDS WITH ANTITUBULIN ACTIVITY | NEW YORK UNIVERSITY (US) | 2003-04-24 | — | — | WO | disclosed |
| US-6552018-B1 | As antitumor agents | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-04-22 | — | — | US | disclosed |
| EP-1103551-A1 | PYRAZOLE DERIVATIVES AND SALTS THEREOF | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-05-30 | — | — | EP | disclosed |
| US-6169086-B1 | AN ANTITUMOR AGENT FOR TREATING TUMOR RESISTANT TO 5-FLUOROURACIL TYPE DRUGS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122009-A1 | Trisubstituted triazine compounds, and methods for making and using the compounds, which have antitubulin activity | TUBA1C, TUBB1, TUBB | PIK3CA 4651/4885MAPT 36/4885SMN1; SMN2 4365/4885 |
| US-20040225125-A1 | Solid phase synthesis of novel biaryl triazine library by suzuki cross coupling | BOLA2; BOLA2B, BRDT, SBDS | PIK3CA 4110/4885MAPT 3155/4885SMN1; SMN2 3731/4885 |
| US-20100239500-A1 | SUBSTITUTED TRIAZINE COMPOUNDS FOR NERVE REGENERATION | GAP43, NTRK2, NGF | PIK3CA 3259/4885MAPT 336/4885SMN1; SMN2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.