Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 14/20 | 0.37 |
| ▸ | FNTB | P49356 | 14/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 13/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7165817 | 0.86 | FNTA (0.40) | FNTAFNTBPGGT1BPRMT5WDR77 | |
| SCHEMBL6413460 | 0.77 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL7165905 | 0.76 | FNTA (0.37) | FNTAFNTBPGGT1BPRMT5WDR77 | |
| SCHEMBL7165194 | 0.74 | FNTA (0.35) | FNTAFNTBPGGT1BPRMT5WDR77 | |
| SCHEMBL7168181 | 0.73 | FNTA (0.41) | FNTAFNTBPGGT1BGPR6 | |
| SCHEMBL7566909 | 0.71 | FNTA (0.41) | FNTAFNTBPGGT1B | |
| SCHEMBL7168685 | 0.71 | FNTA (0.47) | FNTAFNTBPGGT1B | |
| SCHEMBL6434433 | 0.69 | FNTA (0.45) | FNTAFNTBPGGT1B | |
| SCHEMBL7648190 | 0.68 | FNTA (0.55) | FNTAFNTBPGGT1BGPR6JAK2 | |
| SCHEMBL6471063 | 0.68 | FNTA (0.53) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |