Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409385 | 0.87 | PRMT5 (0.36) | PRMT5WDR77DPP4 | |
| SCHEMBL6412550 | 0.78 | PRMT5 (0.34) | PRMT5WDR77 | |
| SCHEMBL7168702 | 0.77 | FNTA (0.37) | PRMT5WDR77 | |
| SCHEMBL6413464 | 0.76 | — | — | |
| SCHEMBL6408970 | 0.75 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL6411741 | 0.73 | FNTA (0.34) | PRMT5WDR77 | |
| SCHEMBL7161945 | 0.72 | PRMT5 (0.32) | PRMT5WDR77DPP4 | |
| SCHEMBL7566917 | 0.72 | BCAT2 (0.32) | PRMT5WDR77 | |
| SCHEMBL6409378 | 0.72 | HTR1A (0.35) | — | |
| SCHEMBL7167119 | 0.71 | PRMT5 (0.32) | PRMT5WDR77DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |