Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048156 | 0.94 | BCHE (0.54) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL7168899 | 0.91 | ABCB1 (0.59) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL4048160 | 0.85 | ABCB1 (0.58) | CYP3A4CYP1A2CYP2D6BLMBCHE | |
| SCHEMBL8789562 | 0.80 | ABCG2 (0.69) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL8808386 | 0.80 | MAPT (0.45) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL9826705 | 0.80 | ALOX15 (0.69) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL8789662 | 0.79 | ABCG2 (0.64) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL8789246 | 0.78 | ABCG2 (0.66) | CYP3A4CYP1A2CYP2D6KDM4ECYP2C8 | |
| SCHEMBL8807015 | 0.77 | ABCG2 (0.44) | CYP3A4CYP1A2CYP2D6BLMPMP22 | |
| SCHEMBL8789962 | 0.77 | ABCG2 (0.65) | CYP3A4CYP1A2CYP2D6ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934276-B1 | ANTHRANILIC ACID DERIVATIVES AS MULTI DRUG RESISTANCE MODULATORS | XENOVA LTD (GB) | 2003-12-17 | — | — | EP | claimed |
| US-6218393-B1 | IN THERAPY OF MULTIDRUG RESISTANT CANCERS, FOR EXAMPLE TO POTENTIATE CYTOTOXICITY OF CANCER DRUG | XENOVA LIMITED (GB) | 2001-04-17 | — | — | US | claimed |