Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8808386 | 0.97 | MAPT (0.45) | ABCG2SMPD1ABCB1MAPTLMNA | |
| SCHEMBL8809632 | 0.94 | BCHE (0.44) | ABCG2ABCB1MAPTLMNAGAA | |
| SCHEMBL8808236 | 0.92 | MAPT (0.45) | ABCG2SMPD1ABCB1MAPTLMNA | |
| SCHEMBL8807951 | 0.92 | BCHE (0.45) | ABCG2ABCB1MAPTLMNAGAA | |
| SCHEMBL8809566 | 0.91 | BCHE (0.43) | ABCG2ABCB1MAPTLMNAGAA | |
| SCHEMBL8808101 | 0.91 | BCHE (0.43) | ABCG2ABCB1MAPTLMNAGAA | |
| SCHEMBL8807068 | 0.90 | KCNH2 (0.44) | ABCG2MAPTLMNAGAAKDM4E | |
| SCHEMBL8809638 | 0.90 | F10 (0.42) | ABCG2ABCB1MAPTLMNAGAA | |
| SCHEMBL8806058 | 0.90 | ABCB1 (0.43) | ABCG2SMPD1ABCB1LMNAKDM4E | |
| SCHEMBL8807954 | 0.89 | F10 (0.43) | ABCG2ABCB1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |
| EP-0649410-B1 | ANILIDE DERIVATIVES | GLAXO LAB SA (FR) | 1997-05-02 | — | — | EP | disclosed |