Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7166777 | 0.89 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL7165573 | 0.88 | NOTUM (0.53) | ALDH1A1SMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL7168695 | 0.87 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2LMNAMAPTTP53 | |
| SCHEMBL7171864 | 0.87 | GABRA2 (0.55) | ALDH1A1SMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL3493852 | 0.86 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL7166626 | 0.86 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL3491845 | 0.86 | NOTUM (0.57) | ALDH1A1SMN1; SMN2NOTUMLMNAMAPT | |
| SCHEMBL7169434 | 0.86 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2NOTUMLMNAMAPT | |
| SCHEMBL7166760 | 0.86 | NOTUM (0.55) | ALDH1A1SMN1; SMN2NOTUMLMNARAB9A | |
| SCHEMBL27514687 | 0.85 | NOTUM (0.52) | ALDH1A1NOTUMMAPTGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030013754-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION | 2003-01-16 | — | — | US | claimed |
| EP-1244620-A1 | CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-10-02 | — | — | EP | claimed |
| WO-2001047880-A1 | CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | claimed |
| US-6569890-B2 | Antiinflamamtory agents | ICOS CORPORATION | 2003-05-27 | — | — | US | disclosed |
| US-20030013754-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION | 2003-01-16 | — | — | US | disclosed |
| EP-1244620-A1 | CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-10-02 | — | — | EP | disclosed |
| US-6372777-B1 | ENZYME INHIBITORS TREATMENT OF INFLAMMATORY DISEASES AND OTHER DISEASES INVOLVING ELEVATED LEVELS OF CYTOKINES, AS WELL AS CENTRAL NERVOUS SYSTEM (CNS) DISORDERS, | ICOS CORPORATION | 2002-04-16 | — | — | US | disclosed |
| WO-2001047880-A1 | CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013754-A1 | Cyclic AMP-specific phosphodiesterase inhibitors | PDE4A, PDE4B, PDE4C | ALDH1A1 1410/4885SMN1; SMN2 1296/4885NOTUM 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.