Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | MMP16 | P51512 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7174040 | 0.81 | TAAR1 (0.39) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL7168979 | 0.76 | BACE1 (0.40) | BACE1MMP1MMP2MMP3MMP9 | |
| SCHEMBL7168974 | 0.74 | MMP2 (0.63) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL8675411 | 0.70 | HDAC1 (0.53) | MMP1MMP2MMP3MMP8ANPEP | |
| SCHEMBL6341887 | 0.70 | HDAC1 (0.53) | MMP1MMP2MMP3MMP8ANPEP | |
| SCHEMBL2842461 | 0.64 | HDAC4 (0.81) | PTGS2 | |
| SCHEMBL6341820 | 0.62 | KMT2A (0.45) | MMP1MMP2MMP3LMNA | |
| Biphenyl SCHEMBL402802 | 0.61 | TAAR1 (0.51) | MMP1MMP2MMP3MMP9MMP8 | |
| SCHEMBL10141816 | 0.61 | HDAC1 (0.50) | BACE1LMNAMAPT | |
| SCHEMBL403964 | 0.61 | TAAR1 (0.44) | PTGS2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |