Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 3/20 | 0.40 |
| ▸ | MMP2 | P08253 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | MMP16 | P51512 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7174038 | 0.83 | TAAR1 (0.39) | PRCPMMP2MMP3MMP1LTA4H | |
| SCHEMBL7168974 | 0.76 | MMP2 (0.63) | MMP2MMP3MMP1TNFADAM17 | |
| SCHEMBL7168987 | 0.76 | BACE1 (0.37) | BACE1MMP2MMP3MMP1ANPEP | |
| SCHEMBL8675411 | 0.68 | HDAC1 (0.53) | MMP2MMP3MMP1TNFADAM17 | |
| SCHEMBL6341887 | 0.68 | HDAC1 (0.53) | MMP2MMP3MMP1TNFADAM17 | |
| SCHEMBL7173728 | 0.66 | TAAR1 (0.40) | BACE1PRCPLTA4HANPEPALDH1A1 | |
| SCHEMBL402104 | 0.65 | MEN1 (0.42) | PRCP | |
| SCHEMBL398964 | 0.64 | PTGS2 (0.46) | PRCPALDH1A1MAPTHPGD | |
| SCHEMBL4876495 | 0.64 | TAAR1 (0.44) | PRCP | |
| SCHEMBL403964 | 0.64 | TAAR1 (0.44) | PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |