Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7170250 | 1.00 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7174498 | 1.00 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7170246 | 0.85 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7170243 | 0.85 | PDE4B (0.53) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7172425 | 0.85 | LMNA (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7172429 | 0.85 | LMNA (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6584635 | 0.84 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7174936 | 0.83 | PDE4B (0.66) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7175061 | 0.83 | PDE4B (0.66) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7177909 | 0.83 | PDE4B (0.66) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900212-B1 | CHIRAL PHENYLDIHYDROFURANONES AS PDE-IV INHIBITORS | SCHERING AG (DE) | 2003-12-17 | — | — | EP | claimed |
| US-6011060-A | TREATING A DISEASE MEDIATED BY ACTIVATION OF THE TUMOR NECROSIS FACTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-01-04 | — | — | US | claimed |
| EP-0900212-B1 | CHIRAL PHENYLDIHYDROFURANONES AS PDE-IV INHIBITORS | SCHERING AG (DE) | 2003-12-17 | — | — | EP | disclosed |
| US-6011060-A | TREATING A DISEASE MEDIATED BY ACTIVATION OF THE TUMOR NECROSIS FACTOR | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-01-04 | — | — | US | disclosed |