Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1628688 | 0.96 | ALDH1A1 (0.61) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| SCHEMBL7265324 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| SCHEMBL25044804 | 0.80 | HTR2C (0.51) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL11476722 | 0.80 | HTR2C (0.51) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL31343737 | 0.78 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| Hydrochloric Acid SCHEMBL30282981 | 0.78 | HTR2C (0.50) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL27242692 | 0.78 | HTR2C (0.50) | ALDH1A1KDM4EMAPTKMT2AMEN1 | |
| SCHEMBL25045262 | 0.78 | CYP1A2 (0.52) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| SCHEMBL8080267 | 0.77 | ALDH1A1 (0.91) | ALDH1A1KDM4EMAPTGAAKMT2A | |
| SCHEMBL27242706 | 0.76 | CHRM2 (0.37) | ALDH1A1KDM4EMAPTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124606-B2 | Substituted 7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3′,2′-e]pyrazin-6(6aH)-ones | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-02-28 | — | — | US | disclosed |