SCHEMBL25045262

SCHEMBL25045262

CN1CCN2c3ncccc3NC(=O)C2C1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.52
CHRM2 P08172 2/20 0.52
CYP2D6 P10635 2/20 0.52
CHRM1 P11229 2/20 0.52
HTR1A P08908 1/20 0.52
ADRA2A P08913 1/20 0.52
CYP2C9 P11712 1/20 0.52
TSHR P16473 1/20 0.52
ADRA2B P18089 1/20 0.52
ADRA2C P18825 1/20 0.52
DRD1 P21728 1/20 0.52
HTR2A P28223 1/20 0.52
HTR2C P28335 1/20 0.52
CYP2C19 P33261 1/20 0.52
HTR7 P34969 1/20 0.52
ADRA1A P35348 1/20 0.52
HRH1 P35367 1/20 0.52
DRD3 P35462 1/20 0.52
HTR2B P41595 1/20 0.52
HTR3A P46098 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27242706 0.81 CHRM2 (0.37) CYP1A2CHRM2CYP2D6CHRM1ALDH1A1
SCHEMBL1628688 0.80 ALDH1A1 (0.61) ALDH1A1KDM4EMAPTMEN1HPGD
SCHEMBL25045261 0.79 HTR2A (0.43) CYP1A2CHRM2CYP2D6CHRM1HTR1A
SCHEMBL717057 0.78 ALDH1A1 (0.56) CHRM2CHRM1ALDH1A1CHRM4KDM4E
SCHEMBL25045250 0.78 HTR2C (0.35) CYP1A2CHRM2CYP2D6CHRM1HTR1A
SCHEMBL24675020 0.78 ALDH1A1 (0.49) CYP1A2CHRM2CYP2D6CHRM1HTR1A
SCHEMBL24675035 0.78 ALDH1A1 (0.49) CYP1A2CHRM2CYP2D6CHRM1HTR1A
SCHEMBL11453737 0.78 KDM4E (0.62) CYP1A2CHRM2CYP2D6CHRM1HTR1A
SCHEMBL11476722 0.77 HTR2C (0.51) CYP1A2CYP2D6CYP2C9HTR2AHTR2C
SCHEMBL25044804 0.77 HTR2C (0.51) CYP1A2CYP2D6CYP2C9HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023016521-A1 SUBSTITUTED TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF 上海赛默罗生物科技有限公司 2023-02-16 WO disclosed