Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5949786 | 0.93 | ALDH1A1 (0.47) | ALDH1A1CYP3A4MAPTTDP1TSHR | |
| SCHEMBL7113012 | 0.89 | ALDH1A1 (0.46) | ALDH1A1CYP3A4MAPTTDP1TSHR | |
| SCHEMBL7121790 | 0.83 | TSHR (0.45) | ALDH1A1CYP3A4MAPTTDP1TSHR | |
| SCHEMBL7734435 | 0.81 | TSHR (0.48) | ALDH1A1CYP3A4MAPTTDP1TSHR | |
| SCHEMBL7124662 | 0.81 | ALDH1A1 (0.46) | ALDH1A1CYP3A4MAPTTDP1TSHR | |
| SCHEMBL7115457 | 0.80 | GAA (0.48) | ALDH1A1CYP3A4TSHRNPC1TP53 | |
| SCHEMBL8526617 | 0.76 | TSHR (0.45) | ALDH1A1CYP3A4TDP1TSHRHPGD | |
| SCHEMBL31236206 | 0.76 | TSHR (0.45) | ALDH1A1CYP3A4TDP1TSHRHPGD | |
| SCHEMBL28253345 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP3A4MAPTTDP1TSHR | |
| SCHEMBL25247609 | 0.75 | ALDH1A1 (0.41) | ALDH1A1CYP3A4MAPTTDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970100-B1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 2003-11-12 | — | — | EP | disclosed |
| EP-0970100-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-01-12 | — | — | EP | disclosed |
| WO-1998035977-A1 | BENZIMIDAZOLE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |