Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.59 |
| ▸ | NOS1 | P29475 | 7/20 | 0.59 |
| ▸ | NOS2 | P35228 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137403 | 0.74 | NOS3 (1.00) | NOS3NOS1NOS2CYP2D6TAAR1 | |
| SCHEMBL6137325 | 0.69 | NOS3 (0.52) | NOS3NOS1NOS2 | |
| SCHEMBL6137718 | 0.69 | NOS3 (0.52) | NOS3NOS1NOS2GAA | |
| SCHEMBL6137311 | 0.65 | NOS1 (1.00) | NOS3NOS1NOS2 | |
| SCHEMBL6137615 | 0.62 | NOS3 (0.68) | NOS3NOS1NOS2KDM1A | |
| SCHEMBL6137634 | 0.60 | NOS3 (0.48) | NOS3NOS1NOS2GAA | |
| SCHEMBL6137338 | 0.60 | NOS3 (0.48) | NOS3NOS1NOS2KDM4E | |
| SCHEMBL6137722 | 0.59 | NOS3 (0.74) | NOS3NOS1NOS2KDM1A | |
| SCHEMBL6137654 | 0.59 | NOS3 (0.68) | NOS3NOS1NOS2 | |
| SCHEMBL10357310 | 0.58 | KDM4E (0.41) | NOS3NOS1NOS2KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6579883-B1 | Nitrogen monoxide synthases; 4-amino-8-bromo-3a-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta (c) quinoline; neurodegenerative, autoimmune, cardiovascular diseases | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-06-17 | — | — | US | disclosed |