SCHEMBL717351

SCHEMBL717351

CC(C)[Si](C#Cc1c2ccccc2c2cc3ccc4c(C#C[Si](C(C)C)(C(C)C)C(C)C)c5ccccc5c5cc6ccc1c2c6c3c45)(C(C)C)C(C)C

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CACNA2D1 P54289 1/20 0.34
CACNB2 Q08289 1/20 0.34
CACNA1C Q13936 1/20 0.34
CYP1A2 P05177 3/20 0.30
CYP1A1 P04798 1/20 0.30
CYP1B1 Q16678 1/20 0.30
FYN P06241 2/20 0.30
ACHE P22303 2/20 0.30
AHR P35869 2/20 0.30
ERBB2 P04626 1/20 0.30
MAOA P21397 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LCK P06239 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
MAPT P10636 1/20 0.30
SLC6A2 P23975 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL715009 0.88 CACNA2D1 (0.39) CACNA2D1CACNB2CACNA1C
SCHEMBL10022715 0.88 CACNA2D1 (0.39) CACNA2D1CACNB2CACNA1C
SCHEMBL30360377 0.83 CACNA2D1 (0.35) CACNA2D1CACNB2CACNA1CCYP1A2CYP1A1
SCHEMBL14514097 0.83 CACNA2D1 (0.35) CACNA2D1CACNB2CACNA1CCYP1A2CYP1A1
SCHEMBL29537640 0.82 CACNA2D1 (0.41) CACNA2D1CACNB2CACNA1CALDH1A1MAPT
SCHEMBL4462408 0.82 CACNA2D1 (0.41) CACNA2D1CACNB2CACNA1CALDH1A1MAPT
SCHEMBL21821368 0.82 CYP1A2 (0.33) CACNA2D1CACNB2CACNA1CCYP1A2FYN
SCHEMBL17231135 0.82 CACNA2D1 (0.36) CACNA2D1CACNB2CACNA1C
SCHEMBL10090590 0.81 CACNA2D1 (0.38) CACNA2D1CACNB2CACNA1CCYP1A2CYP1A1
SCHEMBL10090594 0.81 CYP1A2 (0.43) CYP1A2CYP1A1CYP1B1FYNACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120048377-A1 PHOTOSENSITIVE OPTOELECTRONIC DEVICES COMPRISING POLYCYCLIC AROMATIC COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2012-03-01 US disclosed
US-20120048377-A1 PHOTOSENSITIVE OPTOELECTRONIC DEVICES COMPRISING POLYCYCLIC AROMATIC COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2012-03-01 US disclosed
WO-2010099583-A1 PHOTOSENSITIVE OPTOELECTRONIC DEVICES COMPRISING POLYCYCLIC AROMATIC COMPOUNDS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-09-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120048377-A1 PHOTOSENSITIVE OPTOELECTRONIC DEVICES COMPRISING POLYCYCLIC AROMATIC COMPOUNDS TYR, PAH, DDT CACNA2D1 1837/4885CACNB2 2464/4885CACNA1C 1891/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.