Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24819490 | 0.81 | ALDH1A1 (0.46) | KDM4EALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL716608 | 0.77 | KMT2A (0.52) | KDM4EKMT2AALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL361031 | 0.77 | CYP3A4 (0.41) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL65673 | 0.76 | KMT2A (0.59) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL17942583 | 0.76 | CYP3A4 (0.43) | KDM4EKMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL28151465 | 0.74 | KDM4E (0.50) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL27430582 | 0.74 | CYP3A4 (0.49) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL14380289 | 0.73 | KMT2A (0.56) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13639510 | 0.73 | HTR2A (0.50) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL10444960 | 0.73 | HRH3 (0.62) | KDM4EMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | claimed |
| US-20160317533-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2016-11-03 | — | — | US | claimed |
| US-20150374687-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | claimed |
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |
| US-20160317533-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2016-11-03 | — | — | US | disclosed |
| US-20160317533-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2016-11-03 | — | — | US | disclosed |
| US-20160317533-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2016-11-03 | — | — | US | disclosed |
| US-20150374687-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | disclosed |
| US-20150374687-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | MERCK PATENT GMBH (DE) | 2015-12-31 | — | — | US | disclosed |
| US-20120049727-A1 | Organometallic Complex, and Light-Emitting Device and Electronic Appliance Using the Same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2012-03-01 | — | — | US | disclosed |
| US-8053974-B2 | Organometallic complex, and light emitting device and electronic appliance using the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-8053974-B2 | Organometallic complex, and light emitting device and electronic appliance using the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-8053974-B2 | Organometallic complex, and light emitting device and electronic appliance using the same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| US-20090033209-A1 | Organometallic Complex, And Light Emitting Device And Electronic Appliance Using the Same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| US-20090033209-A1 | Organometallic Complex, And Light Emitting Device And Electronic Appliance Using the Same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| US-20090033209-A1 | Organometallic Complex, And Light Emitting Device And Electronic Appliance Using the Same | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1866321-A1 | ORGANOMETALLIC COMPLEX, AND LIGHT-EMITTING DEVICE AND ELECTRONIC APPLIANCE USING THE SAME | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006104177-A1 | ORGANOMETALLIC COMPLEX, AND LIGHT-EMITTING DEVICE AND ELECTRONIC APPLIANCE USING THE SAME | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120049727-A1 | Organometallic Complex, and Light-Emitting Device and Electronic Appliance Using the Same | AFF1, AP3M1, AP2M1 | KDM4E 1033/4885MEN1 649/4885KMT2A 515/4885 |
| US-20150374687-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | GRM4, GRIK4, GRIA4 | KDM4E 369/4885MEN1 4409/4885KMT2A 793/4885 |
| US-20090033209-A1 | Organometallic Complex, And Light Emitting Device And Electronic Appliance Using the Same | AFF1, AP3M1, AP2M1 | KDM4E 1055/4885MEN1 634/4885KMT2A 534/4885 |
| US-20160317533-A1 | SUBSTITUTED QUINOXALINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR4 | GRM4, GRIA4, GRIK4 | KDM4E 379/4885MEN1 4389/4885KMT2A 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.