Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.52 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5911760 | 0.87 | HSD11B1 (0.67) | HSD11B1HSD17B1HSD17B2ADRB2ADRB1 | |
| SCHEMBL7137179 | 0.84 | HSD11B1 (0.58) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL7166097 | 0.81 | HSD11B1 (0.57) | HSD11B1HSD17B1HSD17B2KMT2AMEN1 | |
| SCHEMBL7146931 | 0.81 | HSD11B1 (0.46) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL5911680 | 0.80 | HSD11B1 (0.69) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL3622383 | 0.77 | HSD11B1 (0.66) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL20899769 | 0.77 | HSD11B1 (0.62) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL3620379 | 0.77 | HSD11B1 (0.60) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL4968140 | 0.77 | HSD11B1 (0.64) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A | |
| SCHEMBL3602689 | 0.76 | HSD11B1 (0.66) | HSD11B1HSD17B1HSD17B2KMT2AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283833-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001090091-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | disclosed |