Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.46 |
| ▸ | CTPS1 | P17812 | 6/20 | 0.39 |
| ▸ | KDM1A | O60341 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618471 | 0.89 | HSD11B1 (0.58) | HSD11B1HSD17B1HSD17B2CTPS1KDM1A | |
| SCHEMBL7175079 | 0.81 | HSD11B1 (0.52) | HSD11B1HSD17B1HSD17B2CTPS1KDM1A | |
| SCHEMBL3620013 | 0.79 | HSD11B1 (0.62) | HSD11B1HSD17B1HSD17B2CTPS1KDM1A | |
| SCHEMBL3618947 | 0.77 | HSD11B1 (0.62) | HSD11B1HSD17B1HSD17B2CTPS1KDM1A | |
| SCHEMBL7166097 | 0.75 | HSD11B1 (0.57) | HSD11B1HSD17B1HSD17B2CTPS1POLB | |
| SCHEMBL3605829 | 0.74 | HSD11B1 (0.58) | HSD11B1HSD17B1HSD17B2CTPS1KDM1A | |
| SCHEMBL7137179 | 0.74 | HSD11B1 (0.58) | HSD11B1HSD17B1HSD17B2CTPS1KDM1A | |
| SCHEMBL5831417 | 0.73 | ALDH1A1 (0.42) | HSD11B1HSD17B1HSD17B2ALDH1A1 | |
| SCHEMBL5831058 | 0.72 | HSD11B1 (0.43) | HSD11B1HSD17B1HSD17B2 | |
| SCHEMBL27534009 | 0.72 | HSD11B1 (0.69) | HSD11B1HSD17B1HSD17B2KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283831-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001090090-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | disclosed |