Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.74 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28147345 | 0.88 | PTGS2 (0.74) | PTGS2PTGS1TGFBR1SCD | |
| SCHEMBL8442044 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL8229590 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1TGFBR1SCD | |
| SCHEMBL4889545 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1TGFBR1 | |
| SCHEMBL8483738 | 0.81 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL28146262 | 0.79 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL8483933 | 0.79 | PTGS2 (0.78) | PTGS2PTGS1 | |
| SCHEMBL57318 | 0.79 | KDM4E (0.50) | PTGS2PTGS1TGFBR1 | |
| SCHEMBL8621133 | 0.79 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL790509 | 0.78 | PTGS2 (0.75) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582690-B1 | PROCESS FOR PREPARATION OF 2, 3-DIARYL-5-SUBSTITUTED PYRIDINES AND THEIR INTERMEDIATES | GLENMARK GENERICS LTD (IN) | 2018-07-25 | — | — | EP | disclosed |
| EP-2582690-A1 | PROCESS FOR PREPARATION OF 2, 3-DIARYL-5-SUBSTITUTED PYRIDINES AND THEIR INTERMEDIATES | Glenmark Generics Limited (IN) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011158250-A1 | PROCESS FOR PREPARATION OF 2, 3-DIARYL-5-SUBSTITUTED PYRIDINES AND THEIR INTERMEDIATES | GLENMARK GENERICS LIMITED (IN) | 2011-12-22 | — | — | WO | disclosed |
| EP-1282423-A2 | PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC | Oklahoma Medical Research Foundation (US) | 2003-02-12 | — | — | EP | disclosed |
| US-20030017148-A1 | Prevention of insulin-dependent diabetes, complications thereof, or allograft rejection by inhibition of cyclooxygenase-2 activity | OKLAHOMA MEDICAL RESEARCH FOUNDATION | 2003-01-23 | — | — | US | disclosed |
| WO-2001085175-A2 | PREVENTION OF INSULIN-DEPENDENT DIABETES, COMPLICATIONS THEREOF, OR ALLOGRAFT REJECTION BY INHIBITION OF CYCLOOXYGENASE-2 ACTIVITY WITH NS398 OR PDTC | OKLAHOMA MEDICAL RESEARCH FOUNDATION (US) | 2001-11-15 | — | — | WO | disclosed |