Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 2/20 | 0.39 |
| ▸ | CCR8 | P51685 | 2/20 | 0.39 |
| ▸ | LPO | P22079 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197434 | 0.98 | HTR2C (0.47) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7171164 | 0.96 | HTR2C (0.46) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7172386 | 0.96 | HTR2C (0.46) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7173179 | 0.96 | HTR2C (0.46) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7176249 | 0.96 | HTR2C (0.46) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7179318 | 0.96 | HTR2C (0.46) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| SCHEMBL4109690 | 0.89 | CCR1 (0.54) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| SCHEMBL12877216 | 0.85 | HTR2C (0.42) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| SCHEMBL5265171 | 0.85 | HTR2C (0.42) | HTR2CHTR2ABRD4KDM4EL3MBTL1 | |
| SCHEMBL12075550 | 0.82 | KDM4E (0.40) | HTR2CHTR2ABRD4KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |