Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7183136 | 0.97 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7179297 | 0.97 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7181174 | 0.97 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7176568 | 0.97 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7182526 | 0.97 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7185467 | 0.97 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7183700 | 0.92 | GRM5 (0.35) | NOS2ALDH1A1HTTELANE | |
| Hydrochloric Acid SCHEMBL7177918 | 0.91 | NOS2 (0.36) | TLR8NOS2ALDH1A1MAPTHTT | |
| Hydrochloric Acid SCHEMBL7175253 | 0.90 | TLR8 (0.33) | TLR8KCNH2NOS2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7182234 | 0.89 | GRM5 (0.35) | NOS2ALDH1A1HTTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |