Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 5/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ESR1 | P03372 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CYP19A1 | P11511 | 13/20 | 0.53 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.53 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | SNCA | P37840 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12379610 | 0.89 | HSD17B1 (1.00) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL1977286 | 0.89 | HSD17B1 (1.00) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL2835007 | 0.86 | HSD17B1 (0.74) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL7921185 | 0.85 | HSD17B1 (0.76) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL7921186 | 0.85 | HSD17B1 (0.76) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL2838564 | 0.84 | HSD17B1 (0.58) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL7701951 | 0.84 | HSD17B1 (0.58) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL12593631 | 0.82 | HSD17B1 (0.79) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL8205348 | 0.82 | HSD17B1 (0.79) | HSD17B1LMNAESR1MAPK1CYP19A1 | |
| SCHEMBL2831329 | 0.79 | HSD17B1 (0.63) | HSD17B1LMNAESR1MAPK1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0715517-B1 | ESTRENE STEROIDS AS NEUROCHEMICAL INITIATORS OF CHANGE IN HUMAN HYPOTHALAMIC FUNCTION AND RELATED PHARMACEUTICAL COMPOSITIONS | PHERIN PHARM INC (US) | 2003-11-05 | — | — | EP | claimed |