Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ACLY | P53396 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63977 | 0.96 | THRB (0.58) | THRBACLYALDH1A1L3MBTL1TSHR | |
| SCHEMBL8409587 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| Water SCHEMBL22069810 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| SCHEMBL6843552 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| Fluoride SCHEMBL1898636 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| SCHEMBL3693057 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| SCHEMBL621694 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| SCHEMBL5963066 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| SCHEMBL15750748 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR | |
| Water SCHEMBL31538153 | 0.93 | THRB (0.55) | THRBACLYALDH1A1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6664431-B2 | Catalytic pyrolysis of halogenated acid; decarboxylation | Zakrytoe Aktsionernoe Obschestvo Nauchno-Proizvodstvennoe Obiedinenie “Pim-Invest” (RU) | 2003-12-16 | — | — | US | disclosed |
| EP-1285904-A1 | Process for producing fluorinated aliphatic compounds | Igumnov, Sergei Mikhailovich (RU) | 2003-02-26 | — | — | EP | disclosed |
| US-20020177742-A1 | Process for producing fluorinated aliphatic compounds | ZAKRYTOE AKTSIONERNOE OBSCHESTVO NAUCHNO-PROIZVODSTVENNOE OBIEDINENIE "PIM-INVEST" (RU) | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177742-A1 | Process for producing fluorinated aliphatic compounds | KCNN3, KCNN2, KCNN1 | THRB 1365/4885ACLY 2352/4885ALDH1A1 4608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.