Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | HTR2A | P28223 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.57 |
| ▸ | PLD1 | Q13393 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7177015 | 1.00 | DRD2 (0.62) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| SCHEMBL26666399 | 0.93 | DRD2 (0.70) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL16989758 | 0.85 | DRD2 (0.61) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL16989757 | 0.85 | DRD2 (0.61) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| SCHEMBL29364904 | 0.84 | DRD2 (0.64) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| SCHEMBL655853 | 0.84 | DRD2 (0.64) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| SCHEMBL15599597 | 0.84 | DRD2 (0.60) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL2995613 | 0.83 | DRD2 (0.62) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| Bromide SCHEMBL11205803 | 0.83 | DRD2 (0.62) | DRD2HTR1AADRA2AHTR2ASLC6A4 | |
| SCHEMBL10316252 | 0.82 | DRD2 (0.76) | DRD2HTR1AADRA2AHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |