Sugi Predict

Sugi Predict / Compounds / SCHEMBL7177486

SCHEMBL7177486

SCHEMBL7177486

COc1ccc(Br)c(OC)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C)cc(C)cc1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 2/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ CYP2D6 P10635 1/20 0.43
▸ CYP2C19 P33261 1/20 0.43
▸ ATM Q13315 1/20 0.42
▸ LMNA P02545 2/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MAPT P10636 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.36
▸ TUBB4A P04350 1/20 0.36
▸ TUBB P07437 1/20 0.36
▸ TUBA3C P0DPH7 1/20 0.36
▸ TUBA1B P68363 1/20 0.36
▸ TUBA4A P68366 1/20 0.36
▸ TUBB4B P68371 1/20 0.36
▸ TUBB3 Q13509 1/20 0.36
▸ TUBB2A Q13885 1/20 0.36
▸ TUBB8 Q3ZCM7 1/20 0.36
▸ TUBA3E Q6PEY2 1/20 0.36
▸ TUBA1A Q71U36 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187377 0.92 ATM (0.43) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7174918 0.91 HPGD (0.42) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7188501 0.91 CYP1A2 (0.41) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7183212 0.89 HPGD (0.42) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7182502 0.87 TAS1R3 (0.41) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7189320 0.86 HPGD (0.44) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7183053 0.86 HPGD (0.44) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7175781 0.85 TAS1R3 (0.40) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7185485 0.84 ATM (0.44) HPGDCYP1A2CYP2D6CYP2C19ATM
SCHEMBL7179743 0.84 HPGD (0.39) HPGDCYP1A2CYP2D6CYP2C19ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 HPGD 3983/4885CYP1A2 1595/4885CYP2D6 1673/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 HPGD 4041/4885CYP1A2 2020/4885CYP2D6 2229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.