Sugi Predict

Sugi Predict / Compounds / SCHEMBL7188501

SCHEMBL7188501

SCHEMBL7188501

COc1ccc(Br)c(OC)c1P(=O)(C(=O)c1ccccc1)C(=O)c1c(C)cc(C(C)(C)C)cc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 3/20 0.41
▸ HPGD P15428 2/20 0.41
▸ CYP2C19 P33261 2/20 0.41
▸ CYP2D6 P10635 1/20 0.41
▸ ATM Q13315 1/20 0.40
▸ LMNA P02545 3/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ MAPT P10636 2/20 0.37
▸ TP53 P04637 1/20 0.37
▸ ALDH1A1 P00352 3/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ NR1H4 Q96RI1 3/20 0.35
▸ PPARG P37231 2/20 0.35
▸ PPARA Q07869 2/20 0.35
▸ TUBB4A P04350 1/20 0.35
▸ TUBB P07437 1/20 0.35
▸ TUBA3C P0DPH7 1/20 0.35
▸ TUBA1B P68363 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7187082 0.93 ATM (0.41) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7177486 0.91 HPGD (0.43) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7174918 0.88 HPGD (0.42) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7182641 0.88 ATM (0.38) CYP1A2HPGDCYP2C19ATMLMNA
SCHEMBL7183212 0.87 HPGD (0.42) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7189133 0.86 TAS1R3 (0.38) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7189320 0.84 HPGD (0.44) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7188507 0.83 SMN1; SMN2 (0.38) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7187377 0.83 ATM (0.43) CYP1A2HPGDCYP2C19CYP2D6ATM
SCHEMBL7183053 0.83 HPGD (0.44) CYP1A2HPGDCYP2C19CYP2D6ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 CYP1A2 1595/4885HPGD 3983/4885CYP2C19 1820/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 CYP1A2 2020/4885HPGD 4041/4885CYP2C19 2313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.