Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | DRD3 | P35462 | 7/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179971 | 1.00 | USP30 (0.42) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL7179973 | 1.00 | USP30 (0.42) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL7181646 | 0.90 | USP30 (0.44) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL7181651 | 0.90 | USP30 (0.44) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL7181656 | 0.90 | USP30 (0.44) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL6820526 | 0.86 | USP30 (0.49) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL6820477 | 0.86 | USP30 (0.49) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL6819527 | 0.82 | DRD2 (0.51) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL6820522 | 0.82 | DRD2 (0.51) | USP30DRD2DRD3HTR2AMTNR1A | |
| SCHEMBL7024099 | 0.82 | MTNR1A (0.43) | USP30DRD2DRD3HTR2AMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1014985-B1 | A COMBINATION OF A 5-HT REUPTAKE INHIBITOR AND A H5-HT 1B ANTAGONIST OR PARTIAL AGONIST | ASTRAZENECA AB (SE) | 2003-05-21 | — | — | EP | claimed |