Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | NOS1 | P29475 | 6/20 | 0.55 |
| ▸ | NOS3 | P29474 | 4/20 | 0.55 |
| ▸ | NOS2 | P35228 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7176136 | 0.96 | HRH4 (0.66) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Bromide SCHEMBL11596227 | 0.82 | HRH4 (0.66) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Dimaprit SCHEMBL7173650 | 0.82 | HRH4 (1.00) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| SCHEMBL11597746 | 0.80 | CYP1A2 (0.64) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Dimaprit SCHEMBL379810 | 0.79 | HRH4 (1.00) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Hydrochloric Acid SCHEMBL11596112 | 0.78 | CYP1A2 (0.62) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Dimaprit SCHEMBL7174665 | 0.78 | HRH4 (0.96) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Dimaprit SCHEMBL30836911 | 0.78 | HRH4 (0.96) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| SCHEMBL29174444 | 0.75 | HRH4 (0.58) | HRH4CYP1A2TDP1ALDH1A1HRH2 | |
| Bromide SCHEMBL4732426 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655914-B1 | Use of Histamine-2 agonists for treatment of sexual dysfunction | NAHOUM CESAR ROBERTO DIAS (BR) | 2003-02-26 | — | — | EP | disclosed |
| US-5773457-A | Compositions | Nahoum, Cesar Roberto Dias (BR) | 1998-06-30 | — | — | US | disclosed |
| EP-0655914-A4 | NOVEL COMPOSITIONS. | NAHOUM CESAR ROBERTO DIAS (BR) | 1998-04-22 | — | — | EP | disclosed |
| EP-0655914-A1 | NOVEL COMPOSITIONS | NAHOUM, Cesar Roberto Dias (BR) | 1995-06-07 | — | — | EP | disclosed |
| WO-1994004120-A2 | METHODS OF TREATING SEXUAL DYSFUNCTION IN ANIMALS WITH AND H AGONIST | NAHOUM CESAR ROBERTO DIAS (BR) | 1994-03-03 | — | — | WO | disclosed |