Dimaprit

Dimaprit

SCHEMBL379810

CN(C)CCCSC(=N)N

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 5/20 1.00
CYP1A2 P05177 5/20 1.00
TDP1 Q9NUW8 4/20 1.00
ALDH1A1 P00352 2/20 1.00
HRH2 P25021 1/20 1.00
HSD17B10 Q99714 1/20 0.88
NOS1 P29475 7/20 0.58
NOS3 P29474 4/20 0.58
NOS2 P35228 4/20 0.58
CYP2C19 P33261 3/20 0.54
MAPT P10636 2/20 0.46
TSHR P16473 2/20 0.46
LMNA P02545 2/20 0.44
CYP3A4 P08684 2/20 0.44
APEX1 P27695 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP2D6 P10635 2/20 0.42
BLM P54132 1/20 0.41
HRH3 Q9Y5N1 1/20 0.40
NPC1 O15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimaprit SCHEMBL7174665 0.98 HRH4 (0.96) HRH4CYP1A2TDP1ALDH1A1HRH2
Dimaprit SCHEMBL30836911 0.98 HRH4 (0.96) HRH4CYP1A2TDP1ALDH1A1HRH2
Dimaprit SCHEMBL7173650 0.98 HRH4 (1.00) HRH4CYP1A2TDP1ALDH1A1HRH2
SCHEMBL12648461 0.93 HSD17B10 (1.00) HRH4CYP1A2TDP1ALDH1A1HRH2
Hydrochloric Acid SCHEMBL7367775 0.91 ALDH1A1 (1.00) HRH4CYP1A2TDP1ALDH1A1HRH2
SCHEMBL7216548 0.86
Hydrochloric Acid SCHEMBL3588464 0.84 ALDH1A1 (0.73) HRH4CYP1A2TDP1ALDH1A1HRH2
Hydrochloric Acid SCHEMBL7176136 0.79 HRH4 (0.66) HRH4CYP1A2TDP1ALDH1A1HRH2
Bromide SCHEMBL7180345 0.79 HRH4 (0.69) HRH4CYP1A2TDP1ALDH1A1HRH2
SCHEMBL11597746 0.78 CYP1A2 (0.64) HRH4CYP1A2TDP1ALDH1A1HRH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 688 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12251478-B2 Bioactive polymeric dressing for accelerated wound closure ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2025-03-18 US claimed
US-20240261459-A1 BIOACTIVE POLYMERIC DRESSING FOR ACCELERATED WOUND CLOSURE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-08-08 US claimed
US-11896724-B2 Bioactive polymeric dressing for accelerated wound closure ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2024-02-13 US claimed
US-20210100927-A1 BIOACTIVE POLYMERIC DRESSING FOR ACCELERATED WOUND CLOSURE ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY 2021-04-08 US claimed
EP-2841566-B1 DERIVATION OF NEURAL STEM CELLS AND DOPAMINERGIC NEURONS FROM HUMAN PLURIPOTENT STEM CELLS INT STEM CELL CORPORATION (US) 2019-03-13 EP claimed
US-20140107124-A1 NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES ALLERGAN, INC. (US) 2014-04-17 US claimed
US-20100143322-A1 USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE PLT PATENT & LICENCE TRADING LTD., C/O THE B-NET (GB) 2010-06-10 US claimed
US-20090156581-A1 Aminergic pharmaceutical compositions and methods BOARD OF TRUSTREES OF MICHIGAN STATE UNIVERSITY (US) 2009-06-18 US claimed
EP-1917006-A2 USE OF INHIBITORS OF N-METHYL TRANSFERASES FOR THE THERAPY OF PARKINSON'S DISEASE PLT Patent & Licence Trading Ltd. (GB) 2008-05-07 EP claimed
US-20080039507-A1 Novel Prostamides For The Treatment Of Glaucoma And Related Diseases ALLERGAN, INC. 2008-02-14 US claimed
US-5952361-A Compositions DIAS NAHOUM CESAR ROBERTO (US) 1999-09-14 US claimed
US-5908853-A THERAPY FOR SEXUAL DISORDERS Nahoum, Cesar Roberto Dias (BR) 1999-06-01 US claimed
WO-1999020265-A1 COMPOSITIONS CONTAINING HISTAMINE H2 AGONISTS AND METHODS OF USE IN TREATING DRY EYE ALCON LABORATORIES, INC. (US) 1999-04-29 WO claimed
EP-0655914-A4 NOVEL COMPOSITIONS. NAHOUM CESAR ROBERTO DIAS (BR) 1998-04-22 EP claimed
US-5728378-A ANTITUMOR AND ANTIVIRUS AGENTS MAXIM PHARMACEUTICALS, INC. (US) 1998-03-17 US claimed
EP-0655914-A1 NOVEL COMPOSITIONS NAHOUM, Cesar Roberto Dias (BR) 1995-06-07 EP claimed
EP-0652768-A1 PREPARATION FOR ACTIVATION OF NATURAL KILLER CELLS (NK-CELLS), SAID PREPARATION CONTAINING INTERFERON-ALPHA AND HISTAMINE, SEROTONIN OR SUBSTANCES WITH CORRESPONDING RECEPTOR ACTIVITY MAXIM PHARMACEUTICALS, INC. (US) 1995-05-17 EP claimed
WO-1994004120-A2 METHODS OF TREATING SEXUAL DYSFUNCTION IN ANIMALS WITH AND H AGONIST NAHOUM CESAR ROBERTO DIAS (BR) 1994-03-03 WO claimed
WO-1993024144-A1 PREPARATION FOR ACTIVATION OF NATURAL KILLER CELLS (NK-CELLS), SAID PREPARATION CONTAINING INTERFERON-α AND HISTAMINE, SEROTONIN OR SUBSTANCES WITH CORRESPONDING RECEPTOR ACTIVITY SYNTELLO INC. (US) 1993-12-09 WO claimed
US-4474876-A Flow cytometric analysis of histamine receptors TRUSTEES OF BOSTON UNIVERSITY (US) 1984-10-02 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140107124-A1 NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES PTGIS, PTGIR, PTGS1 HRH4 613/4885CYP1A2 1157/4885TDP1 1517/4885
US-20080039507-A1 Novel Prostamides For The Treatment Of Glaucoma And Related Diseases PTGIS, PTGIR, PTGS1 HRH4 613/4885CYP1A2 1157/4885TDP1 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.