Sugi Predict

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SCHEMBL7180571

SCHEMBL7180571

COCCOc1ccc(PC(=O)c2c(C)cccc2Cl)c(C)c1.[LiH]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.43
▸ TDP1 Q9NUW8 2/20 0.43
▸ ALDH1A1 P00352 3/20 0.38
▸ FFAR1 O14842 2/20 0.38
▸ MCL1 Q07820 2/20 0.37
▸ PPARG P37231 1/20 0.37
▸ PPARD Q03181 1/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ SRC P12931 1/20 0.37
▸ MRGPRX4 Q96LA9 1/20 0.36
▸ POLB P06746 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ HTR1A P08908 1/20 0.35
▸ DRD2 P14416 1/20 0.35
▸ HTR2A P28223 1/20 0.35
▸ L3MBTL1 Q9Y468 2/20 0.35
▸ ATM Q13315 1/20 0.34
▸ TYK2 P29597 1/20 0.34
▸ TRPM4 Q8TD43 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7186701 0.97 KDM4E (0.45) KDM4ETDP1ALDH1A1FFAR1MCL1
SCHEMBL7188420 0.92 TDP1 (0.39) KDM4ETDP1ALDH1A1FFAR1PPARG
SCHEMBL7179737 0.91 KDM4E (0.39) KDM4ETDP1ALDH1A1FFAR1MCL1
SCHEMBL7190316 0.91 KDM4E (0.41) KDM4ETDP1ALDH1A1FFAR1MCL1
SCHEMBL7183768 0.90 KMT2A (0.40) KDM4ETDP1ALDH1A1FFAR1MCL1
SCHEMBL7180649 0.90 MCL1 (0.40) KDM4EALDH1A1MCL1PPARGPPARD
SCHEMBL7180489 0.89 FFAR1 (0.44) KDM4ETDP1ALDH1A1FFAR1MCL1
SCHEMBL7182236 0.88 THRA (0.41) MCL1PPARGPPARDMRGPRX4
SCHEMBL7180724 0.87 MCL1 (0.39) KDM4EALDH1A1MCL1MRGPRX4SMN1; SMN2
SCHEMBL7183264 0.87 THRB (0.43) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KDM4E 3226/4885TDP1 4234/4885ALDH1A1 3416/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KDM4E 2651/4885TDP1 4275/4885ALDH1A1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.