Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 6/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7173360 | 0.87 | ICAM1 (0.45) | ICAM1HDAC6CHRM2HTR1ACHRM1 | |
| SCHEMBL8522771 | 0.83 | ICAM1 (0.43) | ICAM1HDAC6CHRM2HTR1ACHRM1 | |
| SCHEMBL6746537 | 0.82 | ICAM1 (0.41) | ICAM1HDAC6MEN1KMT2AALDH1A1 | |
| SCHEMBL8522768 | 0.81 | ICAM1 (0.36) | ICAM1HDAC6CHRM2HTR1ACHRM1 | |
| SCHEMBL6745590 | 0.80 | ICAM1 (0.64) | ICAM1 | |
| SCHEMBL7149885 | 0.76 | ICAM1 (0.53) | ICAM1MEN1KMT2AALDH1A1FAAH | |
| SCHEMBL7144340 | 0.73 | HDAC6 (0.42) | HDAC6CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL8315505 | 0.73 | HDAC6 (0.45) | HDAC6CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL6745150 | 0.72 | HDAC6 (0.44) | HDAC6CHRM2HTR1ACHRM1DRD2 | |
| SCHEMBL6751888 | 0.72 | ICAM1 (0.43) | ICAM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518423-B1 | These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and | EISAI CO., LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-0934941-A1 | BENZOPIPERIDINE DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-08-11 | — | — | EP | disclosed |