Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180918

SCHEMBL7180918

SCHEMBL7180918

COc1c(C)cc(C)c(OC)c1C(=O)P(=O)(C(=O)c1c(Cl)cccc1Cl)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ TAS1R3 Q7RTX0 3/20 0.40
▸ TAS1R1 Q7RTX1 3/20 0.40
▸ TAS1R2 Q8TE23 3/20 0.40
▸ TOP1 P11387 1/20 0.38
▸ NOTUM Q6P988 1/20 0.38
▸ PTGS2 P35354 2/20 0.37
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ LMNA P02545 2/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ TUBB4A P04350 2/20 0.36
▸ TUBB P07437 2/20 0.36
▸ TUBA3C P0DPH7 2/20 0.36
▸ TUBA1B P68363 2/20 0.36
▸ TUBA4A P68366 2/20 0.36
▸ TUBB4B P68371 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7175812 0.95 TAS1R3 (0.41) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1
SCHEMBL7174985 0.93 ALDH1A1 (0.41) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1
SCHEMBL7187008 0.90 ALDH1A1 (0.45) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1
SCHEMBL7189020 0.88 KDM4E (0.40) KDM4ETAS1R3TAS1R1TAS1R2TOP1
SCHEMBL7189336 0.88 TAS1R3 (0.43) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1
SCHEMBL7187776 0.86 CA12 (0.44) ALDH1A1KDM4ETAS1R3TAS1R1TAS1R2
SCHEMBL7187679 0.85 ALDH1A1 (0.54) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1
SCHEMBL7182765 0.85 TAS1R3 (0.45) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1
SCHEMBL7182197 0.84 MEN1 (0.35) KDM4ETAS1R3TAS1R1TAS1R2LMNA
SCHEMBL7187549 0.84 POLB (0.42) ALDH1A1KDM4EHSD17B10TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885KDM4E 3226/4885HSD17B10 56/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885KDM4E 2651/4885HSD17B10 42/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.