Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180936

SCHEMBL7180936

SCHEMBL7180936

COc1cc(OC)c(C(=O)[P](=O)c2ccccc2C(=O)c2c(Cl)ccc(Cl)c2Cl)c(OC)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.40
▸ ABCG2 Q9UNQ0 3/20 0.39
▸ LMNA P02545 1/20 0.37
▸ MAPT P10636 4/20 0.36
▸ CLCN2 P51788 1/20 0.36
▸ MAPK1 P28482 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ MEN1 O00255 1/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ NOD2 Q9HC29 1/20 0.35
▸ CES2 O00748 1/20 0.35
▸ CES1 P23141 1/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ ATM Q13315 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ TUBB4A P04350 1/20 0.35
▸ TUBB P07437 1/20 0.35
▸ TUBA3C P0DPH7 1/20 0.35
▸ TUBA1B P68363 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7178126 0.92 KMT2A (0.41) KMT2AABCG2LMNAMAPTMAPK1
SCHEMBL7175462 0.91 KMT2A (0.45) KMT2AABCG2LMNAMAPTMAPK1
SCHEMBL7174638 0.91 HPGD (0.38) KMT2ALMNAMAPTCLCN2NPC1
SCHEMBL7182505 0.90 KMT2A (0.40) KMT2AABCG2LMNAMAPTMAPK1
SCHEMBL7182106 0.88 KMT2A (0.45) KMT2AABCG2LMNAMAPTMAPK1
SCHEMBL7184065 0.87 KMT2A (0.41) KMT2AABCG2LMNAMAPTMAPK1
SCHEMBL7188977 0.84 MAPT (0.41) KMT2AABCG2MAPTMAPK1MEN1
SCHEMBL7180809 0.84 LMNA (0.39) KMT2ALMNACLCN2KDM4EMEN1
SCHEMBL7181292 0.83 ALDH1A1 (0.38) KMT2AABCG2LMNAMAPTMAPK1
SCHEMBL7736110 0.82 ALDH1A1 (0.43) KMT2AABCG2MAPTMAPK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885ABCG2 3732/4885LMNA 3241/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885ABCG2 4323/4885LMNA 3247/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.