Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 3/20 | 0.34 |
| ▸ | LAP3 | P28838 | 3/20 | 0.34 |
| ▸ | FDPS | P14324 | 3/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | OTC | P00480 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10938189 | 0.89 | KDM4E (0.38) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| SCHEMBL114969 | 0.84 | CTSA (0.48) | KDM4ECTSAACHEALDH1A1POLB | |
| SCHEMBL8626497 | 0.81 | CTSA (0.46) | KDM4ECTSAACHEALDH1A1POLB | |
| SCHEMBL3083684 | 0.80 | KDM4E (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| SCHEMBL11050843 | 0.78 | CTSA (0.39) | KDM4ECTSAACHEALDH1A1POLB | |
| SCHEMBL10395275 | 0.75 | CTSA (0.40) | KDM4ECTSAACHEALDH1A1POLB | |
| SCHEMBL10395316 | 0.75 | CTSA (0.40) | KDM4ECTSAACHEALDH1A1POLB | |
| SCHEMBL1378198 | 0.74 | CTSA (0.43) | KDM4ECTSAACHEALDH1A1POLB | |
| SCHEMBL15185856 | 0.74 | CTSA (0.43) | KDM4EMMP2THRBMAPK1HSD17B10 | |
| SCHEMBL13163283 | 0.73 | KDM4E (0.36) | KDM4EMMP2THRBMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090639-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-07-28 | — | — | US | disclosed |
| US-20140100194-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA, NV (BE) | 2014-04-10 | — | — | US | disclosed |
| US-8629281-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA, NV (BE) | 2014-01-14 | — | — | US | disclosed |
| US-8558011-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA, NV (BE) | 2013-10-15 | — | — | US | disclosed |
| EP-2029614-B1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2013-01-23 | — | — | EP | disclosed |
| US-20120184510-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | COLBURN RAYMOND W (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120053347-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-03-01 | — | — | US | disclosed |
| US-7897781-B2 | Cold menthol receptor-1 antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2011-03-01 | — | — | US | disclosed |
| EP-2029614-A2 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | Janssen Pharmaceutica, N.V. (BE) | 2009-03-04 | — | — | EP | disclosed |
| US-20080287398-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-20 | — | — | US | disclosed |
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-31 | — | — | US | disclosed |
| WO-2007134107-A2 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-22 | — | — | WO | disclosed |
| EP-0479813-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1995-09-20 | — | — | EP | disclosed |
| WO-1990015806-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | Huhtamäki Oy (FI) | 1990-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027029-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | KDM4E 2229/4885MMP2 4515/4885THRB 947/4885 |
| US-20120184510-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | KDM4E 2229/4885MMP2 4515/4885THRB 947/4885 |
| US-20120053347-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | KDM4E 2229/4885MMP2 4515/4885THRB 947/4885 |
| US-20080287398-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | KDM4E 2229/4885MMP2 4515/4885THRB 947/4885 |
| US-20140100194-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | KDM4E 2229/4885MMP2 4515/4885THRB 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.