Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.82 |
| ▸ | PDE4A | P27815 | 16/20 | 0.82 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864287 | 0.90 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7423821 | 0.90 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8510408 | 0.87 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8475654 | 0.87 | PDE4A (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7359794 | 0.87 | PDE4A (0.71) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7362543 | 0.86 | PDE4B (0.69) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8330265 | 0.84 | PDE4A (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7379237 | 0.84 | PDE4A (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8330262 | 0.84 | PDE4A (0.64) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL29025551 | 0.82 | PDE4A (0.59) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071646-A4 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1071645-A4 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2003-04-02 | — | — | EP | disclosed |
| EP-1071645-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-31 | — | — | EP | disclosed |
| EP-1071646-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052848-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |
| WO-1999052847-A1 | PHOSPHODIESTERASE ISOENZYME DENOMINATED 4 (PDE 4) INHIBITING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |