Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 2/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | F3 | P13726 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7181746 | 1.00 | JUN (0.77) | JUNNFKB1MAPTKDM4ENPC1 | |
| SCHEMBL5598760 | 0.87 | JUN (1.00) | JUNNFKB1MAPTKDM4ENPC1 | |
| SCHEMBL5598762 | 0.87 | JUN (1.00) | JUNNFKB1MAPTKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL11970821 | 0.85 | JUN (0.95) | JUNNFKB1MAPTKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL11970816 | 0.85 | JUN (0.95) | JUNNFKB1MAPTKDM4ENPC1 | |
| SCHEMBL11999793 | 0.80 | JUN (0.84) | JUNNFKB1MAPTKDM4ENPC1 | |
| SCHEMBL4421926 | 0.79 | MAPT (0.75) | MAPTNPC1CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL184544 | 0.79 | MAPT (0.75) | MAPTNPC1CYP1A2CYP2D6ALDH1A1 | |
| Hydrochloric Acid SCHEMBL1490918 | 0.78 | JUN (0.81) | JUNNFKB1MAPTKDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL1490919 | 0.78 | JUN (0.81) | JUNNFKB1MAPTKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946190-B1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE OUTGROWTH | VERTEX PHARMA (US) | 2003-09-24 | — | — | EP | disclosed |
| EP-0946190-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | Vertex Pharmaceuticals Incorporated (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998020891-A1 | METHODS AND COMPOSITIONS FOR STIMULATING NEURITE GROWTH USING COMPOUNDS WITH AFFINITY FOR FKBP12 IN COMBINATION WITH NEUROTROPHIC FACTORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1998-05-22 | — | — | WO | disclosed |